About COPD

Millions of people have COPD, but it’s not the same for everyone

You may also have heard COPD (chronic obstructive pulmonary disease) called chronic bronchitis, emphysema, or both. It’s a progressive disease that makes it hard to breathe. Progressive means the disease gets worse over time. While many people have COPD, it does not affect everyone in the same way.

Quick facts:

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Shortness of breath

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Chronic cough

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Excess mucus

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Chest tightness

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Wheezing

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Fatigue and disrupted sleep

  • Coughing, wheezing, and shortness of breath are common
  • Other symptoms like chest tightness, excess mucus, disrupted sleep, and fatigue can also occur
  • You may feel that you never know when symptoms will crop up

The good news is that there are things you can do to help manage your COPD.

  • Avoid smoking or breathing in other lung irritants. For example, secondhand smoke or air pollutants can further irritate your damaged lungs. Maintain a healthy weight and eat nutritious foods, practice good hygiene to help avoid getting sick, write down how you’re feeling physically and emotionally—and talk to your doctor about it

If you’re experiencing COPD symptoms, talk to your doctor about options for maintenance medications.

Treatments: What you need to know

There are different types of COPD medicines

  • Maintenance (long-acting) medicines
    • Taken every day and work over time to help control symptoms
  • Rescue (short-acting) medicines
    • Relieve sudden symptoms, but aren’t meant to be taken every day

Remember, it's important to keep a rescue medicine close by, even when maintenance medicines work well. Not sure if you are on a maintenance medicine? Talk to your doctor.

COPD medicines are generally delivered through a nebulizer or inhaler

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  • Nebulizer
    • Gets medicine into your lungs in a fine mist while you breathe calmly, deeply, and evenly through a mouthpiece until the mist is gone
    • Requires setup and cleaning
  • Inhaler
    • Compact and portable
    • May require you to hold your breath for up to 10 seconds after you activate the device

Some patients with COPD prefer using a nebulizer

  • Normal breathing
    • When you use a nebulizer, you breathe calmly, deeply, and evenly to get the medicine into your lungs*
    • Nebulizers do not require you to hold your breath after you activate the device. Setup and cleanup time required
*The amount of medicine delivered to your lungs will depend on using the nebulizer properly. In addition, the type and condition of your nebulizer are important factors.

Helpful tips to stay healthy

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If you haven’t already quit, please don’t smoke. Do your best to avoid secondhand smoke, dust, fumes, or other irritants that could make symptoms worse.

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Maintain a healthy weight and eat nutritious foods. If you are overweight, losing weight may improve your breathing. If you are underweight, adding a few pounds may improve your strength—which can speed up the time it takes to recover from flare-ups. Talk to your doctor before making any changes to your diet or exercise.

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Protect yourself from getting sick. Use a hand sanitizer, wash your hands, and avoid anyone who may be contagious.

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Practice breathing exercises and ask your doctor if a pulmonary rehab program is right for you.

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Get support from loved ones. COPD can be an emotional burden as well as a physical one.

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How are you feeling? Writing about the physical and emotional impact of COPD can help. Take your notes with you the next time you see your doctor.

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Important Safety Information

What is YUPELRI®?

  • YUPELRI is a prescription medicine used to treat chronic obstructive pulmonary disease (COPD), a long-term (chronic) lung disease that includes chronic bronchitis, emphysema, or both.
  • It is an anticholinergic medicine which helps the muscles around the airway in your lungs stay relaxed to prevent symptoms such as wheezing, cough, chest tightness, and shortness of breath.
  • It is used long-term as 1 vial of YUPELRI, 1 time each day inhaled through your nebulizer to improve symptoms of COPD for better breathing.

What is YUPELRI®?

  • YUPELRI is a prescription medicine used to treat chronic obstructive pulmonary disease (COPD), a long-term (chronic) lung disease that includes chronic bronchitis, emphysema, or both.
  • It is an anticholinergic medicine which helps the muscles around the airway in your lungs stay relaxed to prevent symptoms such as wheezing, cough, chest tightness, and shortness of breath.
  • It is used long-term as 1 vial of YUPELRI, 1 time each day inhaled through your nebulizer to improve symptoms of COPD for better breathing.

Who should not use YUPELRI?

  • Do not use YUPELRI if you have sudden breathing problems. Always have a rescue inhaler with you.
  • Do not use YUPELRI if you have had an allergic reaction to revefenacin, or any of the other ingredients in YUPELRI (sodium chloride, citric acid, sodium citrate).
  • Do not use in children. It is not known if YUPELRI is safe and effective in children.

Before using YUPELRI, tell your healthcare provider about all your medical conditions, including if you:

  • have eye problems such as glaucoma. YUPELRI may make your glaucoma worse.
  • have prostate or bladder problems, or problems passing urine. YUPELRI may make these problems worse.
  • have liver problems.
  • are allergic to any of the ingredients in YUPELRI, or any other medicines.
  • are pregnant or planning to become pregnant. It is not known if YUPELRI may harm your unborn baby.
  • are breastfeeding. It is not known if the medicine in YUPELRI passes into your breast milk and if it can harm your baby.

Tell your healthcare provider about all the medicines you take including prescription and over-the-counter medicines, vitamins, and herbal supplements. YUPELRI and certain other medicines may interact with each other. This may cause serious side effects.

Especially tell your healthcare provider if you take:

  • Other anticholinergics (including tiotropium, ipratropium, aclidinium, umeclidinium, glycopyrrolate)
  • Atropine

Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist each time you get a new medicine.

What are the possible side effects with YUPELRI?

YUPELRI can cause serious side effects, including:

  • Sudden breathing problems immediately after inhaling your medicine. If you have sudden breathing problems immediately after inhaling your medicine, stop using YUPELRI and call your healthcare provider right away.
  • New or worsened eye problems including acute narrow-angle glaucoma. Acute narrow-angle glaucoma can cause permanent loss of vision if not treated. Symptoms may include:
    • Red eyes
    • Blurred vision
    • Seeing halos or bright colors around lights
    • Eye pain or discomfort
    • Nausea or vomiting
  • Urinary retention. People who take YUPELRI may develop new or worse urinary retention. Symptoms of urinary retention may include:
    • difficulty urinating
    • urinating frequently
    • urination in a weak stream or drips
    • painful urination

If you have any of these symptoms, call your healthcare provider right away before taking another dose.

  • Serious allergic reactions. Call your healthcare provider or get emergency medical care if you get any of the following symptoms of a serious allergic reaction:
    • rash
    • hives
    • severe itching
    • swelling of your face, mouth, and tongue
    • difficulty breathing or swallowing

If you have any of these symptoms, stop taking YUPELRI, and call your healthcare provider right away before taking another dose.

Common side effects of YUPELRI include:

  • Cough
  • Runny nose
  • Upper respiratory tract infection
  • Headache
  • Back pain

Tell your healthcare provider if you get any side effects that bother you or that do not go away. These are not all the possible side effects with YUPELRI. Ask your healthcare provider or pharmacist for more information. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I use YUPELRI?

Read the step by step instructions for using YUPELRI at the end of this Patient Information Leaflet

  • YUPELRI is only for use with a nebulizer.
  • Do not use YUPELRI more often than prescribed.
  • Do not mix YUPELRI with other medicines in your nebulizer.
  • Do not use other medicines that contain an anticholinergic for any reason.
  • Do not stop using YUPELRI, even if you are feeling better, unless your healthcare provider tells you to because your symptoms might get worse.
  • Call your healthcare provider or get emergency medical care right away if
    • your breathing problems get worse.
    • you need to use your rescue inhaler medicine more often than usual.
    • your rescue inhaler medicine does not relieve your symptoms.

This summary does not include all the information about YUPELRI and is not meant to take the place of a discussion with your healthcare provider about your treatment.

Please see the full Prescribing Information. For additional information please contact us at 1-800-395-3376.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.