Coverage &
Savings FAQs

YUPELRI is covered by Medicare and most commercial insurance plans

The out-of-pocket cost of YUPELRI varies depending on your insurance coverage. Coverage is not guaranteed, so be sure to check with your insurance provider for coverage rules and restrictions.

Coverage & Savings FAQs

  • Is YUPELRI covered by Medicare?

    YUPELRI is covered by Medicare plans. Your out-of-pocket cost for YUPELRI depends on the type of Medicare insurance you have.

    Medicare Part B (also called Fee-for-Service, Original Medicare, or Red, White, and Blue) covers 80% of the cost of COPD treatments like YUPELRI. You are responsible for paying the remaining 20% of the cost. Medicare Part B also covers most nebulizers as durable medical equipment (DME) for patient use at home.

    Medigap (Medicare Supplemental Insurance) plans help pay for your share of costs that aren’t covered. Policies are standardized and, in most states, named by letters, like Plan G or Plan K; the benefits are the same no matter which insurance company sells them. When you have supplemental insurance in addition to your Medicare Part B coverage, you may pay as little as $0 out of pocket for YUPELRI.

    Medicare Advantage (Part C) is a type of plan offered by private companies and must follow rules set by Medicare. Most Medicare Advantage plans include prescription drug coverage. Medicare Advantage covers 80% of the cost of COPD treatments like YUPELRI; however, out-of-pocket costs may vary based on the insurance provider and plan type. Based on your specific plan, you may be responsible for up to 20% of the remaining cost.

    Medicare Part D helps cover prescription medicines you take regularly to manage chronic conditions, such as COPD. Typically, Medicare Part D is the insurance provider for patients residing in a nursing facility. Your provider may be required to provide some additional information before you can get YUPELRI.

    Remember, coverage is not guaranteed. Be sure to contact your insurance plan to learn more about your specific out-of-pocket costs for YUPELRI.

  • Is YUPELRI covered by my employer’s insurance plan?

    YUPELRI is covered for 73% of people who have commercial or private insurance, including the biggest plans such as Express Scripts, CVS Caremark/Aetna, and Optum Rx. Check with your insurance plan to confirm coverage for YUPELRI.

    Source: Decisions Resources Group (as of 3/14/2024).

    Additionally, ~90% of patients with commercial or employer-sponsored (private) insurance pay $0 out of pocket for YUPELRI.

    Data on file, March 2024, Mylan Specialty L.P., a Viatris Company.

  • What is the YUPELRI Savings Card?

    The YUPELRI Savings Card may help lower your out-of-pocket costs up to 12 fills per calendar year if you have commercial/private insurance.*

    *No other purchase is necessary; conditions and limitations apply. Please see full terms and conditions at This offer is not valid for patients covered by Medicare, Medicaid, or any other federal or state-funded healthcare program or where prohibited by law. Mylan Specialty L.P., a Viatris Company, reserves the right to amend or end this program at any time without notice.

  • What does dual-eligible mean?

    Dual-eligible means you are enrolled in both Medicare and Medicaid. Medicare will cover 80% of the cost of COPD treatments like YUPELRI, and Medicaid will cover up to 20% of the patient's responsibility. You may pay as little as $0 out of pocket for YUPELRI.

  • What if I don’t currently have health insurance or my insurance does not cover YUPELRI?

    If you don’t have insurance or your insurance doesn’t cover YUPELRI, you may be able to receive your medication free of charge through our Patient Assistance Program (PAP).* For more information:

    *You must meet financial and other program-specific criteria to be eligible for assistance.

  • Does Medicaid cover YUPELRI and a nebulizer?

    Coverage for medications such as YUPELRI varies by state, and Medicaid may not be accepted by all pharmacies. Check with your state’s Medicaid plan to confirm coverage for YUPELRI and/or a nebulizer.

    Learn more about Medicaid.

  • What is the list price of YUPELRI?

    The list price of YUPELRI is $1,501.44 for a 30-day supply.* The list price, also referred to as the wholesale acquisition cost or WAC, is the price at which Viatris sells YUPELRI to wholesalers and may not reflect the actual out-of-pocket costs for a patient at the pharmacy. This price is subject to change at Viatris’ discretion. However, YUPELRI is covered by most private and public (such as Medicare and Medicaid) insurance plans. If your insurance covers YUPELRI, your out-of-pocket costs may be significantly lower.

    If you have questions about your insurance plan or about how much YUPELRI will cost for you, contact your insurance provider for your plan details.

    *Data on file (as of 7/02/2024).

Learn more about insurance coverage for YUPELRI

Stay informed about YUPELRI

Receive important updates about YUPELRI® (revefenacin) inhalation solution.

Important safety information

What is YUPELRI®?
  • YUPELRI is a prescription medicine used to treat chronic obstructive pulmonary disease (COPD), a long-term (chronic) lung disease that includes chronic bronchitis, emphysema, or both.
  • It is an anticholinergic medicine which helps the muscles around the airway in your lungs stay relaxed to prevent symptoms such as wheezing, cough, chest tightness, and shortness of breath.
  • It is used long-term as 1 vial of YUPELRI, 1 time each day inhaled through your nebulizer to improve symptoms of COPD for better breathing.
Who should not use YUPELRI?
  • Do not use YUPELRI if you have sudden breathing problems. Always have a rescue inhaler with you.
  • Do not use YUPELRI if you have had an allergic reaction to revefenacin, or any of the other ingredients in YUPELRI (sodium chloride, citric acid, sodium citrate).
  • Do not use in children. It is not known if YUPELRI is safe and effective in children.

Before using YUPELRI, tell your healthcare provider about all your medical conditions, including if you:

  • have eye problems such as glaucoma. YUPELRI may make your glaucoma worse.
  • have prostate or bladder problems, or problems passing urine. YUPELRI may make these problems worse.
  • have liver problems.
  • are allergic to any of the ingredients in YUPELRI, or any other medicines.
  • are pregnant or planning to become pregnant. It is not known if YUPELRI may harm your unborn baby.
  • are breastfeeding. It is not known if the medicine in YUPELRI passes into your breast milk and if it can harm your baby.

Tell your healthcare provider about all the medicines you take including prescription and over-the-counter medicines, vitamins, and herbal supplements. YUPELRI and certain other medicines may interact with each other. This may cause serious side effects.

Especially tell your healthcare provider if you take:

  • Other anticholinergics (including tiotropium, ipratropium, aclidinium, umeclidinium, glycopyrrolate)
  • Atropine

Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist each time you get a new medicine.

What are the possible side effects with YUPELRI?

YUPELRI can cause serious side effects, including:

  • Sudden breathing problems immediately after inhaling your medicine. If you have sudden breathing problems immediately after inhaling your medicine, stop using YUPELRI and call your healthcare provider right away.
  • New or worsened eye problems including acute narrow-angle glaucoma. Acute narrow-angle glaucoma can cause permanent loss of vision if not treated. Symptoms may include:
    • Red eyes
    • Blurred vision
    • Seeing halos or bright colors around lights
    • Eye pain or discomfort
    • Nausea or vomiting
  • Urinary retention. People who take YUPELRI may develop new or worse urinary retention. Symptoms of urinary retention may include:
    • difficulty urinating
    • urinating frequently
    • urination in a weak stream or drips
    • painful urination

If you have any of these symptoms, call your healthcare provider right away before taking another dose.

  • Serious allergic reactions. Call your healthcare provider or get emergency medical care if you get any of the following symptoms of a serious allergic reaction:
    • rash
    • hives
    • severe itching
    • swelling of your face, mouth, and tongue
    • difficulty breathing or swallowing

If you have any of these symptoms, stop taking YUPELRI, and call your healthcare provider right away before taking another dose.

Common side effects of YUPELRI include:

  • Cough
  • Runny nose
  • Upper respiratory tract infection
  • Headache
  • Back pain

Tell your healthcare provider if you get any side effects that bother you or that do not go away. These are not all the possible side effects with YUPELRI. Ask your healthcare provider or pharmacist for more information. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I use YUPELRI?

Read the step-by-step instructions for using YUPELRI in the full Instructions For Use

  • YUPELRI is only for use with a nebulizer.
  • Do not use YUPELRI more often than prescribed.
  • Do not mix YUPELRI with other medicines in your nebulizer.
  • Do not use other medicines that contain an anticholinergic for any reason.
  • Do not stop using YUPELRI, even if you are feeling better, unless your healthcare provider tells you to because your symptoms might get worse.
  • Call your healthcare provider or get emergency medical care right away if
    • your breathing problems get worse.
    • you need to use your rescue inhaler medicine more often than usual.
    • your rescue inhaler medicine does not relieve your symptoms.

This summary does not include all the information about YUPELRI and is not meant to take the place of a discussion with your healthcare provider about your treatment.

Please see the Full Prescribing Information. For additional information, please contact us at 1-800-395-3376.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.